Maybe with SQL, but I wouldnt suggest it, so you have two options:
Query a full list, and then check your condition on each post retrieved.
Save the product of those three fields in another meta field, which can then be queried.
For the second method, it really depends on the context.
if you are handling the saving via wp_insert_post, then you can save this extra meta field via update_post_meta.
if you are not handling the saving on the server, you can hook to the saving via save_post hook, and then use get_post_meta to retrieve the values of each field, and then update_post_meta to save the product on a field of your choice, for example
add_action( 'save_post', 'add_product_meta' ); //triggers for every post saved
function add_product_meta ( $post_id )
$value1 = get_post_meta( $post_id, 'value1_key', true );
$value2 = get_post_meta( $post_id, 'value2_key', true );
$value3 = get_post_meta( $post_id, 'value3_key', true );
$product = $value1 * $value2 * $value3;
update_post_meta( $prod_id, 'product_of_values', $product );
//use 'product_of_values' as your meta_key for the query