I was wondering if there were any drawbacks to using Options -Indexes in my WordPress htaccess file to block access to directories such as uploads, etc.
Wpbeginner has a post on it here
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There are some legitimate use cases for enabling
Indexes but they're probably not applicable to most sites (especially WordPress sites).
Indexes are helpful on file storage mirrors where you want to provide readonly access to a subset of folders & files without having to build your own UI.
As a best practice, yes, disable them globally using