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wp.domReady(() => {
    wp.blocks.unregisterBlockStyle('core/qoute', 'large');
} );

wp.domReady(() => {
    wp.blocks.unregisterBlockStyle('core/quote', 'large');
} );

core/image (2) ["default", "circle-mask"]
core/quote (2) ["default", "large"]
core/button (2) ["fill", "outline"]
core/pullquote (2) ["default", "solid-color"]
core/separator (3) ["default", "wide", "dots"]
core/table (2) ["regular", "stripes"]
core/social-links (3) ["default", "logos-only", "pill-shape"]

wp.domReady(() => {
    // image
    wp.blocks.unregisterBlockStyle('core/image', 'circle-mask');
    wp.blocks.unregisterBlockStyle('core/image', 'default');
    // quote
    wp.blocks.unregisterBlockStyle('core/quote', 'default');
    wp.blocks.unregisterBlockStyle('core/quote', 'large');
    // button
    wp.blocks.unregisterBlockStyle('core/button', 'fill');
    wp.blocks.unregisterBlockStyle('core/button', 'outline');
    // pullquote
    wp.blocks.unregisterBlockStyle('core/pullquote', 'default');
    wp.blocks.unregisterBlockStyle('core/pullquote', 'solid-color');
    // separator
    wp.blocks.unregisterBlockStyle('core/separator', 'default');
    wp.blocks.unregisterBlockStyle('core/separator', 'wide');
    wp.blocks.unregisterBlockStyle('core/separator', 'dots');
    // table
    wp.blocks.unregisterBlockStyle('core/table', 'regular');
    wp.blocks.unregisterBlockStyle('core/table', 'stripes');
    // social-links
    wp.blocks.unregisterBlockStyle('core/social-links', 'default');
    wp.blocks.unregisterBlockStyle('core/social-links', 'logos-only');
    wp.blocks.unregisterBlockStyle('core/social-links', 'pill-shape');
} );

core/image (2) ["default", "rounded"]
core/quote (2) ["default", "large"]
core/button (2) ["fill", "outline"]
core/pullquote (2) ["default", "solid-color"]
core/separator (3) ["default", "wide", "dots"]
core/table (2) ["regular", "stripes"]
core/social-links (3) ["default", "logos-only", "pill-shape"]

wp.domReady(() => {
    // image
    wp.blocks.unregisterBlockStyle('core/image', 'rounded');
    wp.blocks.unregisterBlockStyle('core/image', 'default');
    // quote
    wp.blocks.unregisterBlockStyle('core/quote', 'default');
    wp.blocks.unregisterBlockStyle('core/quote', 'large');
    // button
    wp.blocks.unregisterBlockStyle('core/button', 'fill');
    wp.blocks.unregisterBlockStyle('core/button', 'outline');
    // pullquote
    wp.blocks.unregisterBlockStyle('core/pullquote', 'default');
    wp.blocks.unregisterBlockStyle('core/pullquote', 'solid-color');
    // separator
    wp.blocks.unregisterBlockStyle('core/separator', 'default');
    wp.blocks.unregisterBlockStyle('core/separator', 'wide');
    wp.blocks.unregisterBlockStyle('core/separator', 'dots');
    // table
    wp.blocks.unregisterBlockStyle('core/table', 'regular');
    wp.blocks.unregisterBlockStyle('core/table', 'stripes');
    // social-links
    wp.blocks.unregisterBlockStyle('core/social-links', 'default');
    wp.blocks.unregisterBlockStyle('core/social-links', 'logos-only');
    wp.blocks.unregisterBlockStyle('core/social-links', 'pill-shape');
} );

We begin by finding out which block styles exists via .getBlockTypes(). This will dump it into the console:

With this information, we can deactivate the block styles. For example, if we want to remove the large quote style, we can use the following in our remove-block-styles.js:

We start off by finding out which block styles exists via .getBlockTypes(). This will dump it into the console:

With this information, we can deactivate the block styles as desired. For example, if we want to remove the large quote style, we can use the following in our remove-block-styles.js: