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The GUID should not be used to generate any URLs for the site (caveat below), so it shouldn't hurt to leave them as they are... unless some badly designed plugin decides that GUIDs are a great shortcut to getting an URL. What the GUID is, is a globally unique identifier-- global as in "throughout all space and time". Feed readers use it to keep track of ...

See the Moving WordPress page in the Codex. When your domain name or URLs change - i.e. from http://example.com/blog to http://example.com, or http://example.com to http://newexample.com - there are additional concerns. The files and database can be moved, however references to the old domain name or location will remain in the database, and that can ...