I have a site with more than 300,000 posts (but really little posts) and cheking why is going so slow I've seen that in the hompage it makes something like this:
"Generated in 15.024 seconds. Made 9492 queries to database and 0 cached queries. Memory used - 81.12MB"
Home only displays the first 10 psts and runs a couple of twitter plugins, any idea about how to reduce this massive amount of queries?