I have a blog that gets the usual spam, which Akismet is pretty good with. Not good enough for me to turn off moderation just yet. I am wondering is there a way to "whitelist" a list of readers so their comments can skip moderation and just get posted?
This way comments from people (identified by combination of name, email and site) who have previously approved comments will not require moderation. Rest of comments will.
I find it better to use a different combination
WP Spam Free - stops most automated spam hxxp://www.polepositionmarketing.com/library/wp-spamfree/
Moderate first time commenters - stops first time human spammers
For the odd person who has a problem with WP Spam Free (so far 2 people from 1000s) I also have a backup plan http://wordpress.org/extend/plugins/comment-whitelist/
I also blacklist spam pingback domains so I don't get to see their pingbacks, and on rare occasions I also do the same with an email address or IP addresses - for instance recently there was a whole datacenter with multiple servers having a conversations with themselves, so I just blocked based on the first 2 numbers in the IP address which were common to the servers and I made sure were assigned to the one datacenter.