I'm wondering how to do make a multi-site network with wordpress. The best example I have is the cheezburger network.
Have you looked through the basics?
You can set up subdomains, site.domain.com or subdirectories domain.com/site
Or you can even route domains to the sub sites. Check out that stuff first, as multisite is built in to WP since 3.0
If you had more specific questions you maybe rephrase your question?